Section 1: Identification

Name: Rivaroxaban

Uses:
• MEDICATION
• Anticoagulant[National Library of Medicine's Medical Subject Headings. Rivaroxaban. Online file (MeSH, 2014). Available from, as of November 19, 2013: http://www.nlm.nih.gov/mesh/2014/mesh_browser/MBrowser.html]

Section 2: Hazard(s) Identification

Signal Word(s): Warning

Section 3: Composition/Information on Ingredients

Name: Rivaroxaban

CAS Registry Number: 366789-02-8

UNII: 9NDF7JZ4M3

Synonyms:
• UNII-9NDF7JZ4M3[National Library of Medicine, SIS; ChemIDplus Lite Record for Rivaroxaban (366789-02-8). Available from, as of October 22, 2013: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp]
• 5-Chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)- 1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide[National Library of Medicine, SIS; ChemIDplus Lite Record for Rivaroxaban (366789-02-8). Available from, as of October 22, 2013: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp]
• 2-Thiophenecarboxamide, 5-chloro-N-(((5S)-2-oxo-3-(4-(3-oxo- 4-morpholinyl)phenyl)-5-oxazolidinyl)methyl)-[National Library of Medicine, SIS; ChemIDplus Lite Record for Rivaroxaban (366789-02-8). Available from, as of October 22, 2013: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp]

Section 4: First-Aid Measures

Section 5: Fire-Fighting Measures

Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam. Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.[Selleck Chemicals; Material Safety Data Sheet: Rivaroxaban, Cat. Number S3002, RN 9366789-02-8 (Revision Date: 10/1/2012). Available from, as of November 15, 2013: http://www.selleckchem.com/msds/Rivaroxaban-MSDS.html]

Unusual fire hazard: emits toxic fumes such as carbon monoxide, etc.[Selleck Chemicals; Material Safety Data Sheet: Rivaroxaban, Cat. Number S3002, RN 9366789-02-8 (Revision Date: 10/1/2012). Available from, as of November 15, 2013: http://www.selleckchem.com/msds/Rivaroxaban-MSDS.html]

Section 6: Accidental Release Measures

Accidental release measures. After Inhalation: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves. Measures for cleaning/collecting: absorb solutions with finely- powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material.[Selleck Chemicals; Material Safety Data Sheet: Rivaroxaban, Cat. Number S3002, RN 9366789-02-8 (Revision Date: 10/1/2012). Available from, as of November 15, 2013: http://www.selleckchem.com/msds/Rivaroxaban-MSDS.html]

Section 7: Handling and Storage

• Personal protective equipment as follows: Breathing equipment: NIOSH/MSHA-approved respirator. Protection of hands: chemical-resistant rubber gloves. Eye protection: chemical safety goggles.[Selleck Chemicals; Material Safety Data Sheet: Rivaroxaban, Cat. Number S3002, RN 9366789-02-8 (Revision Date: 10/1/2012). Available from, as of November 15, 2013: http://www.selleckchem.com/msds/Rivaroxaban-MSDS.html]

Section 8: Exposure Controls/Personal Protection

Section 9: Physical and Chemical Properties

White to yellowish powder[Physicians Desk Reference 67th ed. PDR Network, LLC, Montvale, NJ. p. 1278 (2013)]

Odorless[Physicians Desk Reference 67th ed. PDR Network, LLC, Montvale, NJ. p. 1278 (2013)]

log Kow = 2.18 (est)[US EPA; Estimation Program Interface (EPI) Suite. Ver. 4.1. Nov, 2012. Available from, as of Nov 18, 2013: http://www.epa.gov/oppt/exposure/pubs/episuitedl.htm]

In water, 25.05 mg/L at 25 deg C (est)[US EPA; Estimation Program Interface (EPI) Suite. Ver. 4.1. Nov, 2012. Available from, as of Nov 18, 2013: http://www.epa.gov/oppt/exposure/pubs/episuitedl.htm]

Slightly soluble in organic solvents (e.g. acetone, polyethylene glycol 400) and is pratically insoluble in water and aqueous media[Physicians Desk Reference 67th ed. PDR Network, LLC, Montvale, NJ. p. 1278 (2013)]

6.66X10-16 mm Hg at 25 deg C (est)[US EPA; Estimation Program Interface (EPI) Suite. Ver. 4.1. Nov, 2012. Available from, as of Nov 18, 2013: http://www.epa.gov/oppt/exposure/pubs/episuitedl.htm]

Henry's Law constant = 9,46X10-85 atm-cu m/mol at 25 deg C (est)[US EPA; Estimation Program Interface (EPI) Suite. Ver. 4.1. Nov, 2012. Available from, as of Nov 18, 2013: http://www.epa.gov/oppt/exposure/pubs/episuitedl.htm]

Section 10: Stability and Reactivity

Chemical stability
• Stable if stored as directed; avoid strong oxidizing agents[Selleck Chemicals; Material Safety Data Sheet: Rivaroxaban, Cat. Number S3002, RN 9366789-02-8 (Revision Date: 10/1/2012). Available from, as of November 15, 2013: http://www.selleckchem.com/msds/Rivaroxaban-MSDS.html]

Other
• Dangerous products of decomposition: thermal ecomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides.[Selleck Chemicals; Material Safety Data Sheet: Rivaroxaban, Cat. Number S3002, RN 9366789-02-8 (Revision Date: 10/1/2012). Available from, as of November 15, 2013: http://www.selleckchem.com/msds/Rivaroxaban-MSDS.html]

Section 11: Toxicological Information

• Unusual fire hazard: emits toxic fumes such as carbon monoxide, etc.[Selleck Chemicals; Material Safety Data Sheet: Rivaroxaban, Cat. Number S3002, RN 9366789-02-8 (Revision Date: 10/1/2012). Available from, as of November 15, 2013: http://www.selleckchem.com/msds/Rivaroxaban-MSDS.html]

All references are peer reviewed