Section 1: Identification

Name: ACETYLSALICYLIC ACID

Section 2: Hazard(s) Identification

GHS Pictogram

Signal Word(s): Warning

Section 3: Composition/Information on Ingredients

Name: ACETYLSALICYLIC ACID

CAS Registry Number: 50-78-2

UNII: R16CO5Y76E

Section 4: First-Aid Measures

Section 5: Fire-Fighting Measures

SLIGHT WHEN EXPOSED TO HEAT OR FLAME[Sax, N.I. Dangerous Properties of Industrial Materials. 6th ed. New York, NY: Van Nostrand Reinhold, 1984., p. 88]

Section 6: Accidental Release Measures

Section 7: Handling and Storage

Section 8: Exposure Controls/Personal Protection

Vacated 1989 OSHA PEL TWA 5 mg/cu m is still enforced in some states.[NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS (NIOSH) Publication No. 97-140. Washington, D.C. U.S. Government Printing Office, 1997., p. 359]

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 5 mg/cu m.[NIOSH. NIOSH Pocket Guide to Chemical Hazards & Other Databases CD-ROM. Department of Health & Human Services, Centers for Disease Prevention & Control. National Institute for Occupational Safety & Health. DHHS (NIOSH) Publication No. 2005-151 (2005)]

8 hr Time Weighted Avg (TWA): 5 mg/cu m.[American Conference of Governmental Industrial Hygienists TLVs and BEIs. Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices. Cincinnati, OH, 2007, p. 10]

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed three times the TLV-TWA for no more than a total of 30 min during a work day, and under no circumstances should they exceed five times the TLV-TWA, provided that the TLV-TWA is not exceeded.[American Conference of Governmental Industrial Hygienists TLVs and BEIs. Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices. Cincinnati, OH, 2007, p. 5]

Section 9: Physical and Chemical Properties

Monoclinic tablets or needle-like crystals[O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 140]

Colorless to white, crystalline powder.[NIOSH. NIOSH Pocket Guide to Chemical Hazards & Other Databases CD-ROM. Department of Health & Human Services, Centers for Disease Prevention & Control. National Institute for Occupational Safety & Health. DHHS (NIOSH) Publication No. 2005-151 (2005)]

Odorless, but in moist air it is gradually hydrolyzed and acquires odor of acetic acid[O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 140]

Odorless [Note: Develops the vinegar-like odor of acetic acid on contact with moisture].[NIOSH. NIOSH Pocket Guide to Chemical Hazards & Other Databases CD-ROM. Department of Health & Human Services, Centers for Disease Prevention & Control. National Institute for Occupational Safety & Health. DHHS (NIOSH) Publication No. 2005-151 (2005)]

135 deg C (rapid heating)[O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 140]

180.16[O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 140]

pKa = 3.49 at 25 deg C[O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 140]

log Kow = 1.19[Hansch, C., Leo, A., D. Hoekman. Exploring QSAR - Hydrophobic, Electronic, and Steric Constants. Washington, DC: American Chemical Society., 1995., p. 54]

1 g sol in: 300 mL water at 25 deg C, 100 mL water at 37 deg C, 5 mL alcohol, 17 mL chloroform, 10-15 mL ether; less sol in anhydrous ether[O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 140]

In water, 4,600 mg/L at 25 deg C[Yalkowsky SH, Dannenfelser RM; Aquasol Database of Aqueous Solubility. Version 5. College of Pharmacy, University of Arizona - Tucson, AZ (1992)]

Intense mass spectral peaks: 92 m/z, 120 m/z, 138 m/z, 180 m/z[Pfleger, K., H. Maurer and A. Weber. Mass Spectral and GC Data of Drugs, Poisons and their Metabolites. Parts I and II. Mass Spectra Indexes. Weinheim, Federal Republic of Germany. 1985., p. 256]

MAX ABSORPTION (ETHER): 275 NM (LOG E= 3.11); SADTLER REF NUMBER: 51 (IR, PRISM)[Weast, R.C. (ed.). Handbook of Chemistry and Physics. 57th ed. Cleveland: CRC Press Inc., 1976., p. C-191]

UV max: (0.1 N H2SO4): 229 (E(1%)(cm) 484); (CHCl3): 277 (E(1%)(cm) 68)[O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 140]

IR: 5063 (Coblentz Society Spectral Collection)[Lide, D.R., G.W.A. Milne (eds.). Handbook of Data on Organic Compounds. Volume I. 3rd ed. CRC Press, Inc. Boca Raton ,FL. 1994., p. V2: 1347]

UV: 25 (Sadtler Research Laboratories Spectral Collection)[Lide, D.R., G.W.A. Milne (eds.). Handbook of Data on Organic Compounds. Volume I. 3rd ed. CRC Press, Inc. Boca Raton ,FL. 1994., p. V2: 1347]

NMR: 18001 (Sadtler Research Laboratories Spectral Collection)[Lide, D.R., G.W.A. Milne (eds.). Handbook of Data on Organic Compounds. Volume I. 3rd ed. CRC Press, Inc. Boca Raton ,FL. 1994., p. V2: 1347]

Raman: 417 (Sadtler Research Laboratories Spectral Collection)[Lide, D.R., G.W.A. Milne (eds.). Handbook of Data on Organic Compounds. Volume I. 3rd ed. CRC Press, Inc. Boca Raton ,FL. 1994., p. V2: 1347]

MASS: 23813 (NIST/EPA/MSDC Mass Spectral database, 1990 version)[Lide, D.R., G.W.A. Milne (eds.). Handbook of Data on Organic Compounds. Volume I. 3rd ed. CRC Press, Inc. Boca Raton ,FL. 1994., p. V2: 1347]

2.52X10-5 mm Hg at 25 deg C (calc)[Eisenreich SJ et al; Environ Sci Technol 15: 30-8 (1981)]

... solidifies at 118 deg C[O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 140]

Henry's Law constant =: 1.30X10-9 atm-cu m/mole at 25 deg C (est)[SRC; The Physical Properties Database (PHYSPROP). Syracuse, NY: Syracuse Res Corp. Available from, as of January 30, 2008: http://www.syrres.com/esc/physprop.htm]

Hydroxyl radical reaction rate constant = 8.10X10-13 cu cm/molec-sec at 25 deg C (est)[Atkinson R et al; Int J Chem Kinetics 19: 779-828 (1987)]

Section 10: Stability and Reactivity

Section 11: Toxicological Information

All references are peer reviewed